building a collaborative data sharing portal for Alzheimer’s disease research

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# building a collaborative data sharing portal for Alzheimer’s disease research
### kara woo<br>senior bioinformatics engineer<br>sage bionetworks
### 2020-09-04

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# collaborating in search of new Alzheimer's therapies

Traditional approaches haven't worked

We collaborate to tackle problems too big for any one researcher

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# what is sage bionetworks?

A non-profit research institute working to make science more **open**, **collaborative**, and **inclusive**.

![](images/sage-logo.svg)

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# my team at sage

Data Coordinating Center for communities researching neurodegenerative and neuropsychiatric diseases

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# AMP-AD 
### Accelerating Medicines Partnership - Alzheimer’s Disease

- Identifying potential drug targets for Alzheimer’s disease
- We curate and share data from AMP-AD and related groups

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# my work at sage

Helping researchers document and share their data

Developing standards for metadata to enable cross-project collaboration and sharing

Data cleaning and validation

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## curating a dataset used to take >40 emails

![flopping dog with "ugghhh" caption](https://media1.giphy.com/media/nu6h2TlAh0gCY/giphy.gif?cid=3640f6095c7739e54c47333073ee74cd)

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# dccvalidator

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# dccvalidator

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# dccvalidator

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# https://adknowledgeportal.synapse.org/

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# Agora

- Re-analyzed many datasets from the AMP-AD Knowledge Portal to find genes associated with Alzheimer’s disease

- Provides evidence and visualizations to help researchers pick targets to study further

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# https://agora.ampadportal.org

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# conclusions

- Tackling big scientific problems requires collaboration
- Data curation is a big part of any analysis and crucial for making data useful